Job Overview
Location
Wayne, PA, United States of America
Job Type
Full-time
Category
Engineering
Date Posted
April 2, 2026
Full Job Description
đź“‹ Description
- • As a Principal Enterprise Architect within IQVIA's AI and Technology Solutions organization, you will play a pivotal role in shaping the enterprise-wide technology strategy for clinical operations and clinical trial management, ensuring that architectural decisions directly support scalable, compliant, and innovative trial execution across global therapeutic areas.
- • You will co-design and maintain enterprise architecture principles, standards, and reference architectures in close partnership with business, technology, and product leaders, with a specific focus on aligning technology investments to clinical workflows such as study design, site activation, patient recruitment, data collection, and regulatory compliance to reduce technical debt and promote reuse.
- • Your day-to-day responsibilities include defining target enterprise data, AI, and interoperability reference architectures—including event-driven architectures (e.g., Kafka), API management (Apigee, Azure API Management, Kong), and AI/ML platforms (Azure ML, SageMaker)—and ensuring all initiatives adhere to these standards, particularly in clinical domains like EDC integration, clinical data warehousing, and agentic AI for trial feasibility and cohort discovery.
- • You will partner with business units to translate strategies and OKRs into capability- and outcome-based architecture roadmaps that are financially rationalized and focused on enterprise-wide scalability, collaborating with trial operations, site engagement, patient recruitment, and data management leaders to optimize study start-up timelines, site activation efficiency, patient enrollment velocity, and data quality.
- • You will provide an enterprise-wide view of interrelated business and technical capabilities, identifying shared needs and opportunities to consolidate disparate site management tools, EDC platforms, and patient data systems, while pinpointing where agentic AI and automation can reduce manual operational burden in clinical workflows.
- • You will guide senior stakeholders through architectural options, trade-offs, and investment implications using clear, business-focused narratives and models, articulating how architecture decisions impact trial timelines, regulatory risk, site partner experience, and patient enrollment in clinical initiatives.
- • You will translate clinical domain objectives—including study design, regulatory requirements, and site/patient operational constraints—into reusable capability models and architectural blueprints that enable consistent, scalable trial delivery across geographies and therapeutic areas.
- • You will use enterprise architecture tools (LeanIX, Ardoq, MEGA) to define and maintain stable capability models and EA meta-models, mapping capabilities to processes, systems, products, outcomes, and key data domains, and supporting intake of new ideas through formalized architecture governance and portfolio intake processes, including managing financial health across the portfolio.
- • You will govern and rationalize the EA application and tooling portfolio, including inventories of business, data, and technology assets, promoting consistent adoption of standards across the organization and establishing governance for new clinical technology investments to ensure alignment with reference architectures.
- • You will collaborate with business leaders, product managers, domain architects, and technology leaders to identify and mature shared services, platforms, and common patterns, specifically partnering with clinical domain architects and product teams to evolve and standardize architectures for site engagement, patient recruitment, trial data management, and regulatory compliance automation.
- • You will monitor technology and industry trends—especially in AI/ML, data platforms, lakehouse governance, life sciences tech, clinical trial innovation, and agentic AI applications in clinical workflows—and incorporate relevant innovations into enterprise standards and roadmaps, tracking emerging capabilities in decentralized trials, wearable data integration, AI-driven patient matching, and agent-based workflow automation.
- • You will mentor and influence architects and senior engineers to raise architecture maturity and adherence to enterprise standards across delivery teams, developing coaching and reference architectures that enable clinical product and platform teams to build scalable, interoperable solutions aligned to enterprise standards.
🎯 Requirements
- • 15+ years in software development with 10–12+ years in enterprise architecture within large, complex organizations.
- • Demonstrated experience owning enterprise-wide technology strategies and roadmaps, including business architecture, value streams, capability maps, and customer journeys, with applied financial acumen to ensure portfolio health.
- • Recent, relevant enterprise experience with applied data science, AI/ML, and agentic AI solutions, including designing architectures for LLM-based and agent-based systems using vector databases (e.g., Pinecone, Redis), orchestration frameworks (e.g., Lang Chain), and MLOps platforms (e.g., MLflow, Azure ML), with specific hands-on experience in clinical domains such as AI/ML for patient cohort discovery, site feasibility modeling, protocol complexity assessment, or operational forecasting for trial success.
- • Strong enterprise data architecture background, including implementation of data lakehouse architectures on platforms such as Databricks and Snowflake using medallion layering, plus data governance platforms and automation, data catalogs, ontologies, and taxonomies, with demonstrated experience architecting clinical data warehouses, harmonized patient and site data models, and regulatory-compliant data governance for clinical trial data.
- • Deep, hands-on familiarity with clinical operations and clinical trial management, including study design, regulatory pathways, site activation and management, patient recruitment and cohort identification, workflows, protocol adherence monitoring, safety and pharmacovigilance reporting, and trial closeout and data archival, with preference for candidates with direct exposure to site partner needs, patient engagement challenges, and operational constraints that shape how technology can optimize trial delivery.
- • Experience in healthcare or life sciences, with a strong preference for working closely with clinical trial management, clinical operations, or related domains, and direct support of Clinical Operations functions (site operations, patient recruitment, data management, regulatory compliance) and understanding of how technology architecture decisions cascade into operational efficiency, regulatory risk, and trial outcomes.
🏖️ Benefits
- • Competitive base pay range of $118,100.00 - $328,800.00 annually, with actual compensation based on qualifications, experience, location, and schedule.
- • Eligibility for incentive plans, bonuses, and other forms of compensation in addition to base pay.
- • Access to a comprehensive range of health and welfare benefits, including medical, dental, vision, and wellness programs.
- • Opportunity to work remotely with a global leader in healthcare intelligence and clinical research services.
- • Exposure to cutting-edge AI/ML, agentic AI, and data platform innovations within the life sciences and healthcare industries.
- • Professional growth through mentorship, leadership influence, and engagement with senior business, technology, and product leaders across a global enterprise.
Skills & Technologies
Redis
AWS
Azure
REST
Kafka
Senior
Onsite
About IQVIA Holdings Inc.
IQVIA Holdings Inc. provides advanced analytics, technology solutions, and clinical research services to the life-sciences industry. Formed through the 2016 merger of Quintiles and IMS Health, the company integrates healthcare data, analytics, and domain expertise to help biopharmaceutical and medical-device clients optimize drug development, commercialization, and real-world evidence generation. Its offerings span clinical trial design and execution, real-world insights, commercial strategy, and technology platforms that connect stakeholders across the healthcare ecosystem. Headquartered in Durham, North Carolina, IQVIA operates in more than 100 countries, supporting the development and delivery of therapies to improve patient outcomes worldwide.
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