Natera, Inc. logo

Lead Machine Learning and Bioinformatics Scientist

Job Overview

Location

San Carlos, CA

Job Type

Full-time

Category

Machine Learning Engineer

Date Posted

March 11, 2026

Full Job Description

đź“‹ Description

  • • Lead the design, implementation, and rigorous validation of advanced machine learning and statistical methodologies to address complex challenges in cancer diagnostics and monitoring.
  • • Drive the development and refinement of best practices for machine learning model interpretability, ensuring that insights derived from models are understandable and actionable.
  • • Implement robust uncertainty estimation techniques to quantify the confidence in model predictions, crucial for clinical decision-making.
  • • Champion reproducibility in all aspects of model development and deployment, establishing clear pipelines and documentation to ensure consistent and verifiable results.
  • • Design and build sophisticated feature engineering and extraction pipelines specifically tailored for the unique characteristics and complexities of biological data, including genomic and epigenomic information.
  • • Prototype, develop, and productionize machine learning models, leveraging scalable ML infrastructure tools such as MLflow for experiment tracking, Airflow for workflow orchestration, and Docker for containerization to ensure efficient and reliable deployment.
  • • Collaborate intimately with molecular biologists and other domain experts to define experimental designs, ensuring the integrity, quality, and relevance of the generated data for downstream analysis.
  • • Foster a dynamic and collaborative research environment that encourages innovation, scientific rigor, and continuous learning within the Bioinformatics Research and Development team.
  • • Actively contribute to and participate in code reviews and design discussions, providing constructive feedback and upholding high standards for software development and scientific methodology.
  • • Stay abreast of the latest advancements in machine learning, bioinformatics, and cancer epigenomics, and proactively integrate novel techniques and approaches into Natera's research and development efforts.
  • • Mentor and guide junior scientists, sharing expertise and fostering their growth in machine learning and bioinformatics applications.
  • • Translate complex scientific findings and model outputs into clear, concise reports and presentations for both technical and non-technical stakeholders, including leadership and collaborators.
  • • Contribute to the strategic direction of the Bioinformatics R&D team, identifying new opportunities for applying machine learning to Natera's product pipeline and research initiatives.
  • • Ensure compliance with all relevant regulatory requirements and data privacy standards in the development and application of machine learning models for clinical use.
  • • Develop and maintain comprehensive documentation for algorithms, pipelines, and models, ensuring knowledge transfer and long-term maintainability.
  • • Contribute to the publication of research findings in peer-reviewed journals and presentations at scientific conferences, enhancing Natera's scientific reputation.
  • • Evaluate and select appropriate machine learning algorithms and statistical models based on the specific problem, data characteristics, and desired outcomes.
  • • Work with large-scale datasets, ensuring efficient data processing, management, and analysis techniques are employed.
  • • Contribute to the development of intellectual property through invention disclosures and patent applications.
  • • Ensure the ethical application of machine learning in healthcare, considering potential biases and fairness implications.
  • • Drive the continuous improvement of existing machine learning models and pipelines to enhance performance, scalability, and efficiency.
  • • Engage in cross-functional team efforts to integrate machine learning solutions into broader product development lifecycles.
  • • Champion a data-driven culture, promoting the use of evidence-based decision-making throughout the organization.
  • • Proactively identify and mitigate risks associated with machine learning model development and deployment.
  • • Contribute to the strategic planning and roadmap development for the Bioinformatics R&D team.
  • • Ensure the highest standards of scientific integrity and ethical conduct are maintained in all research activities.
  • • Develop and implement strategies for model monitoring and maintenance in production environments.
  • • Collaborate with software engineering teams to ensure seamless integration of machine learning models into production systems.
  • • Contribute to the development of Natera's intellectual property portfolio through research and innovation.
  • • Represent Natera at scientific conferences and industry events, sharing expertise and insights.
  • • Mentor and develop junior team members, fostering a culture of continuous learning and growth.
  • • Drive the adoption of new technologies and methodologies within the team.
  • • Ensure that all research and development activities align with Natera's mission and strategic objectives.
  • • Contribute to the development of Natera's competitive advantage through cutting-edge scientific research and technological innovation.
  • • Play a key role in shaping the future of epigenomic analysis for cancer detection and monitoring through advanced machine learning techniques.
  • • Ensure the robustness and reliability of machine learning models used in clinical diagnostics.
  • • Drive the translation of research findings into tangible product improvements and new product development opportunities.
  • • Foster a collaborative and inclusive work environment that values diverse perspectives and encourages open communication.
  • • Contribute to the overall scientific strategy and vision of the company.
  • • Ensure that Natera remains at the forefront of innovation in the field of machine learning and bioinformatics for oncology.
  • • Develop and implement strategies for effective knowledge management and dissemination within the team and across the organization.
  • • Drive the continuous evolution of Natera's machine learning capabilities to meet the growing demands of the healthcare industry.
  • • Ensure that all machine learning solutions are developed with a patient-centric approach, prioritizing accuracy, safety, and efficacy.
  • • Contribute to the development of Natera's thought leadership in the field of precision medicine.
  • • Drive the implementation of state-of-the-art machine learning techniques for the analysis of complex biological data, with a specific focus on epigenomics in oncology.
  • • Lead the development of novel algorithms and computational approaches to enhance the accuracy and sensitivity of cancer detection and monitoring through cfDNA analysis.
  • • Collaborate with cross-functional teams, including clinical, product, and engineering, to translate research discoveries into impactful diagnostic solutions.
  • • Mentor and guide junior scientists, fostering a culture of scientific excellence and innovation.
  • • Contribute to the strategic planning and execution of research initiatives within the Bioinformatics R&D department.
  • • Ensure the reproducibility and interpretability of machine learning models, adhering to the highest scientific standards.
  • • Drive the development of scalable and efficient machine learning pipelines for processing and analyzing large-scale genomic and epigenomic datasets.
  • • Stay current with the latest advancements in machine learning, bioinformatics, and cancer epigenomics, and proactively integrate new methodologies into Natera's research efforts.
  • • Champion best practices in data science, including version control, testing, and documentation, to ensure robust and maintainable code.
  • • Communicate complex technical concepts effectively to both technical and non-technical audiences.
  • • Contribute to the publication of research findings in high-impact scientific journals and presentations at leading conferences.
  • • Play a pivotal role in shaping Natera's scientific strategy and driving innovation in the field of molecular diagnostics.
  • • Ensure the ethical and responsible application of machine learning in healthcare settings.
  • • Drive the development of novel machine learning models for early cancer detection, recurrence monitoring, and treatment selection.
  • • Foster a collaborative and inclusive research environment that encourages creativity and scientific rigor.
  • • Contribute to the growth and development of the Bioinformatics R&D team through mentorship and knowledge sharing.
  • • Ensure that Natera's machine learning solutions are at the cutting edge of scientific innovation and clinical utility.
  • • Drive the development of robust and interpretable machine learning models for the analysis of complex biological data, with a focus on epigenomics in oncology.
  • • Lead the design and implementation of machine learning algorithms to improve the accuracy and efficiency of cancer diagnostics.
  • • Collaborate with biologists and clinicians to translate research findings into clinically actionable insights.
  • • Mentor junior scientists and contribute to the overall scientific growth of the team.
  • • Drive innovation in machine learning for epigenomic data analysis, contributing to Natera's leadership in the field.
  • • Ensure the reproducibility and scalability of machine learning models and pipelines.
  • • Stay abreast of the latest research and technological advancements in machine learning and bioinformatics.
  • • Communicate research findings effectively to diverse audiences.
  • • Contribute to the strategic direction of the Bioinformatics R&D team.
  • • Champion a culture of scientific excellence and continuous improvement.
  • • Drive the development of novel machine learning approaches for cancer detection and monitoring using cell-free DNA (cfDNA) data.
  • • Lead the design, implementation, and validation of advanced statistical and machine learning models tailored for epigenomic data analysis.
  • • Collaborate closely with cross-functional teams, including molecular biologists, clinicians, and software engineers, to ensure the successful translation of research into clinical applications.
  • • Foster a culture of innovation, scientific rigor, and continuous learning within the Bioinformatics R&D team.
  • • Mentor and guide junior scientists, promoting their professional development and contribution to Natera's research goals.
  • • Drive the adoption of best practices in machine learning development, including model interpretability, uncertainty quantification, and reproducibility.
  • • Contribute to the strategic planning and execution of research initiatives, identifying new opportunities for leveraging machine learning in oncology.
  • • Ensure the highest standards of data integrity and quality control throughout the research and development process.
  • • Communicate complex scientific findings and technical details clearly and effectively to both technical and non-technical stakeholders.
  • • Actively participate in code and design reviews, providing constructive feedback and upholding scientific excellence.
  • • Stay at the forefront of advancements in machine learning, bioinformatics, and cancer epigenomics, and proactively integrate novel techniques into Natera's research pipeline.
  • • Contribute to Natera's intellectual property portfolio through research and innovation.
  • • Drive the development of scalable and efficient machine learning infrastructure to support the analysis of large-scale biological datasets.
  • • Ensure the ethical and responsible application of machine learning in healthcare, with a focus on patient well-being and data privacy.
  • • Champion a data-driven approach to problem-solving and decision-making across the R&D organization.
  • • Contribute to the publication of research findings in peer-reviewed journals and presentations at scientific conferences, enhancing Natera's scientific reputation.
  • • Lead the development of novel machine learning algorithms and statistical models for the analysis of complex biological data, with a specific focus on epigenomics in oncology.
  • • Drive the design and implementation of robust feature engineering pipelines tailored for genomic and epigenomic datasets.
  • • Collaborate with molecular biologists to ensure experimental designs yield high-quality data suitable for advanced machine learning applications.
  • • Foster a culture of scientific excellence, innovation, and collaboration within the Bioinformatics R&D team.
  • • Mentor and guide junior scientists, promoting their technical and scientific growth.
  • • Ensure the reproducibility, interpretability, and uncertainty quantification of machine learning models.
  • • Contribute to the strategic direction of the Bioinformatics R&D department, identifying new research avenues and opportunities.
  • • Drive the development of scalable and efficient machine learning pipelines for processing and analyzing large-scale biological data.
  • • Stay current with the latest advancements in machine learning, bioinformatics, and cancer epigenomics, and proactively integrate new methodologies.
  • • Communicate complex technical concepts effectively to diverse audiences, including leadership, collaborators, and scientific peers.
  • • Contribute to Natera's intellectual property and scientific publications.
  • • Ensure the ethical and responsible application of machine learning in healthcare.
  • • Drive the development of cutting-edge machine learning solutions for cancer diagnostics and monitoring.
  • • Lead the design, implementation, and validation of advanced machine learning and statistical methods for cancer epigenomics.
  • • Collaborate closely with molecular biologists and clinicians to ensure data integrity and relevance for research objectives.
  • • Foster a culture of innovation, scientific rigor, and continuous learning within the Bioinformatics R&D team.
  • • Mentor and guide junior scientists, promoting their professional development and contribution to Natera's research goals.
  • • Drive the adoption of best practices in machine learning development, including model interpretability, uncertainty quantification, and reproducibility.
  • • Contribute to the strategic planning and execution of research initiatives, identifying new opportunities for leveraging machine learning in oncology.
  • • Ensure the highest standards of data integrity and quality control throughout the research and development process.
  • • Communicate complex scientific findings and technical details clearly and effectively to both technical and non-technical stakeholders.
  • • Actively participate in code and design reviews, providing constructive feedback and upholding scientific excellence.
  • • Stay at the forefront of advancements in machine learning, bioinformatics, and cancer epigenomics, and proactively integrate novel techniques into Natera's research pipeline.
  • • Contribute to Natera's intellectual property portfolio through research and innovation.
  • • Drive the development of scalable and efficient machine learning infrastructure to support the analysis of large-scale biological datasets.
  • • Ensure the ethical and responsible application of machine learning in healthcare, with a focus on patient well-being and data privacy.
  • • Champion a data-driven approach to problem-solving and decision-making across the R&D organization.
  • • Contribute to the publication of research findings in peer-reviewed journals and presentations at scientific conferences, enhancing Natera's scientific reputation.
  • • Lead the development of novel machine learning algorithms and statistical models for the analysis of complex biological data, with a specific focus on epigenomics in oncology.
  • • Drive the design and implementation of robust feature engineering pipelines tailored for genomic and epigenomic datasets.
  • • Collaborate with molecular biologists to ensure experimental designs yield high-quality data suitable for advanced machine learning applications.
  • • Foster a culture of scientific excellence, innovation, and collaboration within the Bioinformatics R&D team.
  • • Mentor and guide junior scientists, promoting their technical and scientific growth.
  • • Ensure the reproducibility, interpretability, and uncertainty quantification of machine learning models.
  • • Contribute to the strategic direction of the Bioinformatics R&D department, identifying new research avenues and opportunities.
  • • Drive the development of scalable and efficient machine learning pipelines for processing and analyzing large-scale biological data.
  • • Stay current with the latest advancements in machine learning, bioinformatics, and cancer epigenomics, and proactively integrate new methodologies.
  • • Communicate complex technical concepts effectively to diverse audiences, including leadership, collaborators, and scientific peers.
  • • Contribute to Natera's intellectual property and scientific publications.
  • • Ensure the ethical and responsible application of machine learning in healthcare.
  • • Drive the development of cutting-edge machine learning solutions for cancer diagnostics and monitoring.
  • • Lead the design, implementation, and validation of advanced machine learning and statistical methods for cancer epigenomics.
  • • Collaborate closely with molecular biologists and clinicians to ensure data integrity and relevance for research objectives.
  • • Foster a culture of innovation, scientific rigor, and continuous learning within the Bioinformatics R&D team.
  • • Mentor and guide junior scientists, promoting their professional development and contribution to Natera's research goals.
  • • Drive the adoption of best practices in machine learning development, including model interpretability, uncertainty quantification, and reproducibility.
  • • Contribute to the strategic planning and execution of research initiatives, identifying new opportunities for leveraging machine learning in oncology.
  • • Ensure the highest standards of data integrity and quality control throughout the research and development process.
  • • Communicate complex scientific findings and technical details clearly and effectively to both technical and non-technical stakeholders.
  • • Actively participate in code and design reviews, providing constructive feedback and upholding scientific excellence.
  • • Stay at the forefront of advancements in machine learning, bioinformatics, and cancer epigenomics, and proactively integrate novel techniques into Natera's research pipeline.
  • • Contribute to Natera's intellectual property portfolio through research and innovation.
  • • Drive the development of scalable and efficient machine learning infrastructure to support the analysis of large-scale biological datasets.
  • • Ensure the ethical and responsible application of machine learning in healthcare, with a focus on patient well-being and data privacy.
  • • Champion a data-driven approach to problem-solving and decision-making across the R&D organization.
  • • Contribute to the publication of research findings in peer-reviewed journals and presentations at scientific conferences, enhancing Natera's scientific reputation.

Skills & Technologies

Python
Docker
Pandas
NumPy
Scikit-learn
Senior
Remote
Degree Required

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Natera, Inc. logo
Natera, Inc.
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About Natera, Inc.

Natera is a clinical genetic testing company specializing in cell-free DNA analysis for oncology, women’s health, and organ health. Its core platforms include Panorama for non-invasive prenatal screening, Horizon for carrier screening, Signatera for personalized cancer monitoring, and Prospera for transplant rejection assessment. Laboratories are CLIA-certified and CAP-accredited, supporting physicians, patients, and biopharmaceutical partners worldwide.

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