This job has expired

This position was posted on November 6, 2025 and is likely no longer accepting applications. We've kept it here for historical reference. Check out the similar jobs below!

Immunogenicity Principal Scientist

Zoetis Inc.

Job Overview

Location

Michigan, USA

Job Type

Full-time

Full Job Description

📋 Description

• Shape the future of veterinary medicine by leading immunogenicity strategy for breakthrough protein therapeutics that will improve the lives of millions of companion animals and livestock worldwide.
• Own end-to-end immunogenicity risk assessment for multiple biotherapeutic programs, translating complex immunological data into clear, actionable insights that guide critical go/no-go decisions and regulatory submissions.
• Partner with bioanalytical scientists to design, validate, and troubleshoot anti-drug antibody (ADA) and neutralizing antibody (NAb) assays, ensuring every method meets the highest scientific and regulatory standards.
• Serve as the immunogenicity subject-matter expert for pre-clinical safety and clinical study teams, advising on sampling schedules, assay selection, data interpretation, and clinical impact assessment to safeguard animal health and product success.
• Distill large, multidimensional immunogenicity datasets into concise, compelling narratives for project teams, senior management, and global regulatory agencies, influencing strategic direction and investment priorities.
• Author high-quality sections of IND/CTA filings, study reports, investigator brochures, and regulatory briefing documents, ensuring compliance with FDA, EMA, VICH, and other global guidelines.
• Drive cross-functional collaboration across pharmacology, toxicology, clinical development, CMC, and regulatory affairs, fostering a culture of scientific rigor, transparency, and continuous improvement.
• Champion the adoption of cutting-edge immunogenicity prediction tools, in silico models, and novel assay technologies that reduce animal use, accelerate timelines, and enhance predictive power.
• Mentor junior scientists and bioanalytical colleagues, sharing deep expertise in innate and adaptive immunity, assay development, and regulatory science to elevate team capability and scientific output.
• Proactively monitor emerging literature, regulatory trends, and competitive intelligence to refine Zoetis’ immunogenicity strategy and maintain the company’s position as the global leader in animal health innovation.
• Balance multiple high-priority projects in a fast-paced matrix environment, demonstrating agility in shifting priorities while maintaining meticulous attention to detail and data integrity.
• Contribute to external scientific visibility through peer-reviewed publications, conference presentations, and active participation in industry consortia, reinforcing Zoetis’ reputation for scientific excellence.

🎯 Requirements

• Ph.D. in immunology, pharmacology, biochemistry, or related discipline plus ≥4 years of pharmaceutical or biotechnology industry experience focused on immunogenicity of biotherapeutics.
• Demonstrated track record of peer-reviewed publications and/or regulatory submissions that evidence deep expertise in immunogenicity risk assessment and bioanalytical strategy.
• Comprehensive understanding of innate and adaptive immune mechanisms underlying anti-drug immune responses in veterinary or human biologics.
• Hands-on proficiency with ADA, NAb, and related immunogenicity assays, including cut-point determination, validation, and data interpretation according to global regulatory guidelines.
• Excellent written and verbal communication skills with the ability to convey complex immunological concepts to diverse scientific and non-scientific audiences.
• Nice-to-have: experience with immunogenicity prediction algorithms, statistical cut-point analysis software, and direct interactions with FDA, EMA, or other regulatory agencies.

🏖️ Benefits

• Competitive base salary ranging from $111,000–$181,000 depending on location, plus annual performance bonus and long-term incentive opportunities.
• Comprehensive healthcare, dental, and vision coverage starting day one, with zero-premium options and generous HSA contributions.
• 401(k) plan with 6% company match and additional discretionary profit-sharing, plus pension-style cash balance plan for retirement security.
• Flexible PTO policy, 12 paid holidays, paid volunteer days, and company-wide winter shutdown to recharge and maintain work-life harmony.

Skills & Technologies

Senior

Remote

Ready to Apply?

Apply Externally

You will be redirected to an external site to apply.

Zoetis Inc.

Visit Website

About Zoetis Inc.

Zoetis Inc. discovers, develops, manufactures and commercializes vaccines, medicines and diagnostic products for livestock and companion animals. Founded in 1952 as the animal health division of Pfizer and spun off in 2013, the company operates research, development and manufacturing facilities worldwide, serving veterinarians, livestock producers and pet owners in more than 100 countries. Its portfolio spans parasiticides, anti-infectives, vaccines, medicated feed additives, diagnostics and genetic tests for cattle, swine, poultry, fish, dogs, cats and horses.

View Company Profile