Associate Director/Director, Clinical Operations

BridgeBio Pharma, Inc.

Job Overview

Location

USA

Job Type

Full-time

Full Job Description

📋 Description

• The Associate Director/Director, Clinical Operations role at BridgeBio Pharma is a critical leadership position responsible for overseeing and managing clinical programs from start-up through close-out, ensuring timely delivery of life-changing medicines for patients with rare diseases and unmet medical needs. This role directly supports BridgeBio’s innovative "moneyball for biotech" model by enabling science-driven teams to advance groundbreaking therapies with speed and precision.
• The person will serve as a cross-functional study team lead in a fast-paced, matrix environment, driving clinical development programs forward through strategic planning, execution, and risk mitigation while maintaining the highest standards of quality, compliance, and patient safety.
• Day-to-day responsibilities include representing Clinical Operations in Clinical Development and Global Program Teams; establishing and coordinating study management activities; developing overall study execution plans; managing CRO/vendor relationships including scopes of work, budgets, and payments; directing risk identification, escalation, and resolution; ensuring financial tracking, metrics, and reporting are accurate and timely; contributing to organizational growth through process improvement; and supporting BLA preparation, FDA submissions, and audit readiness.
• The Clinical Operations team at BridgeBio operates within a mission-driven, innovative culture that values curiosity, experimentation, and ethical use of AI to enhance clarity, speed, and quality of work. Employees collaborate with some of the most respected minds in biopharma to reengineer drug development and push boundaries in rare disease therapeutics.
• In this role, the individual will deepen expertise in global clinical trial leadership, regulatory strategy, and cross-functional influence while gaining visibility into end-to-end drug development—from early-stage research to FDA pipeline progression. Success here offers the opportunity to champion patient-centric innovation, build high-performing teams, and directly impact the advancement of transformative medicines.

🎯 Requirements

• BA/BS in a scientific or medical field, or equivalent work experience
• 10+ years of experience managing global clinical trials across all phases of development in the biopharma industry
• Proven experience in cross-functional leadership, including leading data review, database lock, study reporting, BLA preparation, FDA submissions, and audit readiness
• Strong knowledge of GCP and working familiarity with ICH GCP E6 R2 regulations
• Demonstrated ability to manage CRO/vendor relationships, including SOW negotiation, budget tracking, and payments
• Experience in Quality Assurance, SOP and study plan writing, CAPA preparation and closure
• Strong leadership and relationship-building skills in matrix environments, with ability to multi-task in dynamic, fast-paced settings
• Curiosity and adaptability in adopting AI-powered tools to improve work clarity, speed, and quality

🏖️ Benefits

• Market-leading compensation with annual performance bonus and company equity
• 100% employer-paid medical, dental, and vision premiums for employee and dependents
• 401(k) plan with 100% employer match on first 3% and 50% on next 2% of contributions
• Employee Stock Purchase Program (ESPP) and pre-tax commuter benefits
• Unlimited flexible paid time off, paid parental leave (4 months for birthing, 2 months for non-birthing), and company-paid holidays
• Comprehensive mental health support via Spring Health (6 therapy + 6 coaching sessions), fertility and family-forming benefits, FSA/HSA with employer contributions
• Hybrid work model with autonomy over work location and schedule; subsidized lunch via Forkable on in-office days
• Referral program offering $2,500 for successful hires
• Career development through LinkedIn Learning, LifeLabs, BetterUp Coaching, regular feedback, and internal mobility opportunities
• Recognition programs featuring financial rewards, peer-to-peer acknowledgment, and growth pathways

Skills & Technologies

Spring

GCP

Junior

Remote

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BridgeBio Pharma, Inc.

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About BridgeBio Pharma, Inc.

BridgeBio Pharma, Inc. is a commercial-stage biopharmaceutical company focused on genetic diseases and cancers. The company's strategy is to discover, develop, and commercialize precisely targeted medicines for patients with monogenic diseases and cancers for which there are currently no approved therapies. BridgeBio builds a portfolio of potentially life-changing therapies by leveraging its platform technologies and deep scientific expertise. The company's approach involves identifying the underlying genetic cause of a disease and then designing a tailored therapeutic intervention. BridgeBio's pipeline spans various therapeutic areas, including cardiovascular, oncology, and neurology, aiming to address significant unmet medical needs.

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