Observational Research Senior Manager (Pharmacovigilance Epidemiology, Causal Inference, Obesity)
Job Overview
Location
United States - Remote
Job Type
Full-time
Category
Data Science
Date Posted
April 2, 2026
Full Job Description
đź“‹ Description
- • Lead observational research initiatives in pharmacovigilance epidemiology and causal inference to support Amgen’s obesity therapeutic pipeline, generating real-world evidence that informs regulatory submissions, reimbursement decisions, and clinical development strategies.
- • Design and execute causal inference studies using target trial emulation and causal roadmap methodologies to assess disease burden, treatment patterns, safety, and effectiveness of obesity interventions across diverse real-world data sources.
- • Collaborate cross-functionally with clinical, regulatory, HEOR, and commercial teams to identify strategic opportunities where observational research can complement or replace interventional studies, reducing development timelines and costs.
- • Mentor and guide junior researchers in epidemiological methods, study design, and analytical techniques, fostering scientific excellence and innovation within the Center for Observational Research (CfOR).
- • Author peer-reviewed publications, conference abstracts, and internal reports that advance Amgen’s scientific reputation and contribute to external knowledge in obesity epidemiology and pharmacovigilance.
- • Stay current with evolving regulatory expectations for real-world evidence (RWE) from agencies like FDA and EMA, ensuring studies meet rigorous standards for validity, transparency, and reproducibility.
- • Champion the use of secondary data sources including administrative claims, electronic medical records (EMR), and disease registries to enable efficient, scalable evidence generation.
- • Drive continuous improvement in CfOR’s analytical capabilities by contributing to methodological advancements and best practices in observational research.
- • Represent Amgen in scientific forums and external collaborations, positioning the company as a leader in causal inference and obesity epidemiology.
- • Foster an inclusive, science-driven team culture aligned with Amgen’s values of innovation, collaboration, and patient-centricity.
🎯 Requirements
- • Doctorate degree in Epidemiology, Biostatistics, Public Health, or related field with strong observational research focus, OR Master’s degree with 6+ years of relevant research experience, OR Bachelor’s degree with 8+ years of data sciences and scientific experience.
- • Proven experience designing and executing observational research studies using causal inference frameworks such as target trial emulation, instrumental variables, or propensity score methods in pharmaceutical or public health settings.
- • Demonstrated expertise working with secondary data sources including administrative claims (e.g., Medicare, Optum), electronic medical records (EMR), and disease registries to address research questions in obesity, pharmacovigilance, or therapeutic areas.
- • Strong publication record as first or contributing author in peer-reviewed journals, with experience presenting findings at scientific conferences or internal stakeholder forums.
- • Excellent verbal and written communication skills, with ability to translate complex epidemiological concepts for non-technical audiences including clinicians, regulators, and business leaders.
- • Experience working effectively in multi-disciplinary teams and influencing cross-functional stakeholders to adopt observational research solutions for strategic decision-making.
🏖️ Benefits
- • Comprehensive employee benefits package including group medical, dental, and vision coverage, life and disability insurance, flexible spending accounts, and a Retirement and Savings Plan with generous company contributions.
- • Discretionary annual bonus program and stock-based long-term incentives tied to individual and company performance.
- • Award-winning time-off plans and flexible work models, including full remote eligibility, supporting work-life balance and personal well-being.
- • Career development opportunities such as tuition reimbursement, professional training, mentorship programs, and access to internal mobility across Amgen’s global organization.
- • Inclusive, ethical, and science-driven workplace culture committed to diversity, equity, and innovation in service of patients living with serious illnesses.
Skills & Technologies
Senior
Remote
Degree Required
About Amgen Inc.
Amgen Inc. is a global biotechnology company headquartered in Thousand Oaks, California. Founded in 1980, it discovers, develops, manufactures, and delivers human therapeutics targeting cancer, kidney disease, rheumatoid arthritis, bone disease, and other serious illnesses. Using advanced recombinant DNA and molecular biology techniques, Amgen produces biologic medicines such as Neulasta, Enbrel, and Prolia. The company operates R&D, manufacturing, and distribution facilities worldwide, investing heavily in genomic research to identify novel drug targets. Amgen also partners with academic institutions and smaller biotechs to expand its pipeline, aiming to transform breakthrough science into therapies that significantly improve patients’ lives.
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