Job Overview
Location
Woburn, MA Headquarters
Job Type
Full-time
Category
Software Engineering
Date Posted
June 26, 2026
Full Job Description
đź“‹ Description
- • Develop a portfolio of ultrasensitive immunoassays across the product lifecycle, from initial screening and optimization through feasibility, verification, and transfer.
- • Plan, design, and execute hands-on assay-development studies including antibody selection and pairing, reagent conjugation, buffer optimization, reference-material evaluation, matrix characterization, and analytical validation for research and future clinical applications.
- • Translate emerging neuroscience biomarker science into robust assay-design strategies by optimizing for clinically relevant molecular forms, isoforms, post-translational modifications, cleavage fragments, aggregation states, epitopes, and sample types.
- • Analyze data from clinical and preclinical samples and interpret findings in the context of disease biology, sample characteristics, and published literature.
- • Collaborate closely with Platform, Product Development, Operations, and Business Development teams to transition assays from feasibility through verification and transfer.
- • Prepare clear scientific presentations, technical reports, study summaries, abstracts, and publications.
- • Optimize assay strategies to measure low-abundance biomarkers with unprecedented sensitivity using the company’s proprietary SPEAR technology.
- • Identify and evaluate preanalytical variables and matrix effects that impact biomarker measurement in human biofluids.
- • Troubleshoot complex assay-development challenges with scientific rigor and practical problem-solving.
- • Contribute to a rigorous, accountable, and highly collaborative startup environment focused on revolutionizing early disease diagnosis and monitoring.
- • Work onsite five days per week in the Woburn, MA laboratory to conduct experiments and support team collaboration.
- • Apply deep neurobiology knowledge to advance initiatives for ultrasensitive immunoassays targeting neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
- • Demonstrate scientific ownership by independently designing experiments and driving projects from concept to validation.
- • Maintain up-to-date understanding of biomarker heterogeneity and factors influencing measurement in human biofluids.
- • Support the translation of research-grade assays into scalable solutions for clinical applications.
🎯 Requirements
- • Ph.D. in Neuroscience, Neurobiology, Molecular Biology, Biochemistry, Biomedical Engineering, or a closely related field
- • Strong scientific expertise in fluid biomarkers and assay-development strategies for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, or related neurological disorders
- • Hands-on experience developing immunoassays or other quantitative protein-detection methods
- • Demonstrated ability to design experiments independently and troubleshoot technical challenges
- • Evidence of meaningful scientific contributions through peer-reviewed publications, patents, conference presentations, or translational research programs
- • Can work 5 days/week on site in Woburn, MA
🏖️ Benefits
- • Competitive compensation
- • Meaningful stock ownership
- • Comprehensive benefits
- • Great work environment
Skills & Technologies
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About Spear Bio, Inc.
Spear Bio, Inc. is a biotechnology company focused on developing next-generation protein therapeutics using its proprietary computational platform to design and optimize biologics with enhanced stability, efficacy, and manufacturability. The company leverages machine learning and structural biology to target challenging disease areas, including oncology and immunology, with a pipeline of engineered antibodies and protein-based drugs. Spear Bio aims to overcome limitations of traditional biologics by creating molecules that resist degradation and maintain function in harsh physiological conditions. The company collaborates with pharmaceutical partners and has received funding from venture capital firms specializing in life sciences innovation. Its work sits at the intersection of AI-driven drug discovery and protein engineering, positioning it as a leader in the emerging field of computational biologics design.
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