Senior/Principal Statistical Programmer

Xenon

Job Overview

Location

Boston

Job Type

Full-time

Full Job Description

📋 Description

• As a Senior/Principal Statistical Programmer at Xenon Pharmaceuticals, you will play a critical role in advancing neuroscience therapeutics by providing expert SAS programming leadership for clinical trial data analysis, visualization, and reporting that directly supports regulatory submissions and scientific publications for high-impact programs in epilepsy and depression.
• You will ensure the integrity, compliance, and timeliness of clinical data deliverables across multiple Phase 3 studies, acting as a technical authority who bridges biostatistics, data management, and CRO partners to enable data-driven decision-making in Xenon’s mission to develop life-changing treatments for patients with unmet medical needs.
• Day to day, you will manage programming activities at the study level, including overseeing CRO performance to ensure accurate and compliant delivery of SDTM/ADaM datasets, TFLs, and eSUB packages.
• You will author and review programming specifications, develop and validate global SAS macros and utilities to automate routine tasks, and apply advanced SAS/Macro, SAS/SQL, SAS/GRAPH, and SAS/STAT skills to support statistical analysis, regulatory reporting, and ad-hoc requests.
• You will collaborate closely with Biostatistics and data management teams to develop and maintain data review and reporting tools such as aCRF, SAP, and mock review systems, ensuring alignment with statistical analysis plans and ICH guidelines.
• You will provide technical leadership in project timeline management with CRO counterparts, monitoring progress, identifying risks, and ensuring quality and timeliness of statistical programming deliverables.
• You will contribute to the continuous improvement of statistical programming standards by supporting the development of SOPs, best practices, and internal processes that enhance reproducibility, efficiency, and quality across the organization.
• You will mentor junior programmers and foster a culture of excellence through knowledge sharing, code reviews, and adherence to good programming practices in a collaborative, inclusive environment.
• Xenon’s Needham-based team operates in a hybrid model requiring a minimum of two onsite days per week, offering the opportunity to work alongside passionate neuroscientists, clinicians, and data experts dedicated to transforming scientific breakthroughs into tangible patient outcomes.
• In this role, you will deepen your expertise in CDISC standards, regulatory submissions, and CNS therapeutic area programming while gaining visibility into end-to-end clinical development—from Phase 1 through Phase 3—and contributing to Xenon’s growth as a premier integrated neuroscience company.
• You will have the opportunity to lead technical initiatives, influence standardization efforts, and grow into a trusted advisor who shapes how statistical programming supports innovation in one of the most promising pipelines in neuropsychiatry and neurology.

🎯 Requirements

• Bachelor’s degree in a scientific, computer science, or related field; training in statistics preferred.
• Minimum of 5 years of statistical programming experience in pharma, biotech, or CRO environments (8 years required for Principal level).
• Hands-on, expert-level proficiency in SAS/Macro, SAS/SQL, SAS/GRAPH, and SAS/STAT, with demonstrated ability to develop and validate global SAS macros and utilities.
• In-depth knowledge of CDISC standards including SDTM, ADaM, controlled terminologies, aCRF, cSDRG, ADRG, and define.xml.
• Experience managing CROs and overseeing statistical programming activities for clinical trials across multiple phases, particularly in regulatory submission contexts.
• Preferred experience in CNS, pediatric, or rare disease therapeutic areas.

🏖️ Benefits

• Competitive base salary with target bonus and stock options as part of Xenon’s Total Rewards program.
• Comprehensive health benefits including medical, dental, vision, short- and long-term disability, accidental death & dismemberment, and life insurance.
• Retirement savings plan with company matching contributions.
• Generous time off including vacation, personal days, sick days, and an annual company-wide shutdown.
• Employee Assistance Program (EAP) and travel insurance for added peace of mind.
• Expanding Training, Learning & Development program with Tuition Assistance for advanced degrees.
• Hybrid work model based in Boston/Needham with a minimum of two onsite days per week, balancing flexibility and collaboration.
• Opportunity to work on cutting-edge neuroscience programs with high unmet medical need, including Phase 3 epilepsy and depression trials.

Skills & Technologies

REST

Senior

Hybrid

Degree Required

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Xenon

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About Xenon

Xenon is a leading provider of advanced data analytics and artificial intelligence solutions. The company specializes in developing and implementing cutting-edge technologies that help businesses unlock the full potential of their data. Xenon's offerings include predictive modeling, machine learning algorithms, and data visualization tools, all designed to drive informed decision-making and operational efficiency. They serve a diverse range of industries, including finance, healthcare, and retail, empowering clients to gain deeper insights, optimize performance, and achieve strategic business objectives. Xenon is committed to innovation and delivering tangible value through data-driven strategies.

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